Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Indirubin-3|-monoxime
CAS No.: 160807-49-8
Catalog No.: PC-45724Not For Human Use, Lab Use Only.
A potent GSK3β inhibitor with IC50 of 22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $352 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo; also inhibits CDKs at higher concentrations, including Cdk1/cyclin B (IC50=180 nM), Cdk2/cyclin A (IC50~500 nM), Cdk2/cyclin E (IC50=250nM), Cdk4/cyclin D1 (IC50=3.3 uM) and Cdk5/p35 (IC50=100 nM); reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.
| M.Wt | 277.2774 | |
| Formula | C16H11N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 37 mg/mL |
|
| Chemical Name/SMILES |
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro- |
|
1. Leclerc S, et al. J Biol Chem. 2001 Jan 5;276(1):251-60.
2. Hoessel R, et al. Nat Cell Biol. 1999 May;1(1):60-7.
3. Damiens E, et al. Oncogene. 2001 Jun 28;20(29):3786-97.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
